Ag-ZnO 复合纳米粒子增强 Wistar 白化大鼠的伤口愈合活性。
Enhanced wound healing activity of Ag-ZnO composite NPs in Wistar Albino rats.
机构信息
School of Chemistry, Andhra University, Visakhapatnam 533 003, India.
Pharmacy Department, Andhra University, Visakhapatnam 533 003, India.
出版信息
IET Nanobiotechnol. 2018 Jun;12(4):473-478. doi: 10.1049/iet-nbt.2017.0087.
Abstract
In the present study, silver (Ag) and Ag-zinc oxide (ZnO) composite nanoparticles (NPs) were synthesised and studied their wound-healing efficacy on rat model. Ultraviolet-visible spectroscopy of AgNPs displayed an intense surface plasmon (SP) resonance absorption at 450 nm. After the addition of aqueous Zn acetate solution, SP resonance band has shown at 413.2 nm indicating a distinct blue shift of about 37 nm. X-ray diffraction analysis Ag-ZnO composite NPs displayed existence of two mixed sets of diffraction peaks, i.e. both Ag and ZnO, whereas AgNPs exhibited face-centred cubic structures of metallic Ag. Scanning electron microscope (EM) and transmission EM analyses of Ag-ZnO composite NPs revealed the morphology to be monodispersed hexagonal and quasi-hexagonal NPs with distribution of particle size of 20-40 nm. Furthermore, the authors investigated the wound-healing properties of Ag-ZnO composite NPs in an animal model and found that rapid healing within 10 days when compared with pure AgNPs and standard drug dermazin.
摘要
在本研究中，合成了银（Ag）和银-氧化锌（ZnO）复合纳米粒子（NPs），并研究了它们在大鼠模型中的伤口愈合功效。AgNPs 的紫外-可见光谱在 450nm 处显示出强烈的表面等离子体（SP）共振吸收。加入水合乙酸锌溶液后，SP 共振带在 413.2nm 处显示出明显的蓝移，约为 37nm。Ag-ZnO 复合 NPs 的 X 射线衍射分析显示存在两组混合衍射峰，即 Ag 和 ZnO，而 AgNPs 则表现出金属 Ag 的面心立方结构。Ag-ZnO 复合 NPs 的扫描电子显微镜（EM）和透射电镜分析表明，其形态为单分散的六方和准六方 NPs，粒径分布在 20-40nm 之间。此外，作者在动物模型中研究了 Ag-ZnO 复合 NPs 的伤口愈合特性，发现与纯 AgNPs 和标准药物 Dermazin 相比，在 10 天内即可快速愈合。
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