幼崽吮乳比可卡因更具奖赏性：来自功能磁共振成像和三维计算分析的证据。
Pup suckling is more rewarding than cocaine: evidence from functional magnetic resonance imaging and three-dimensional computational analysis.
作者信息
Ferris Craig F, Kulkarni Praveen, Sullivan John M, Harder Josie A, Messenger Tara L, Febo Marcelo
机构信息
Center for Comparative Neuroimaging, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.
出版信息
J Neurosci. 2005 Jan 5;25(1):149-56. doi: 10.1523/JNEUROSCI.3156-04.2005.
Abstract
Nursing has reciprocal benefits for both mother and infant, helping to promote maternal behavior and bonding. To test the "rewarding" nature of nursing, functional magnetic resonance imaging was used to map brain activity in lactating dams exposed to their suckling pups versus cocaine. Suckling stimulation in lactating dams and cocaine exposure in virgin females activated the dopamine reward system. In contrast, lactating dams exposed to cocaine instead of pups showed a suppression of brain activity in the reward system. These data support the notion that pup stimulation is more reinforcing than cocaine, underscoring the importance of pup seeking over other rewarding stimuli during lactation.
摘要
哺乳对母亲和婴儿都有互惠的益处，有助于促进母性行为和母婴联结。为了测试哺乳的“奖赏性”本质，功能性磁共振成像被用于描绘哺乳期母鼠在接触其哺乳幼崽与可卡因时的大脑活动。哺乳期母鼠的哺乳刺激和未生育雌性的可卡因暴露激活了多巴胺奖赏系统。相比之下，接触可卡因而非幼崽的哺乳期母鼠在奖赏系统中表现出大脑活动受到抑制。这些数据支持了幼崽刺激比可卡因更具强化作用这一观点，强调了在哺乳期寻找幼崽相较于其他奖赏性刺激的重要性。
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