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作为波兰华沙艰难梭菌临床分离株流行性决定因素的毒素谱及对大环内酯类和新型氟喹诺酮类药物的耐药性

Toxin profiles and resistances to macrolides and newer fluoroquinolones as epidemicity determinants of clinical isolates of Clostridium difficile from Warsaw, Poland.

作者信息

Pituch Hanna, van Leeuwen Willem, Maquelin Kees, Wultańska Dorota, Obuch-Woszczatyński Piotr, Nurzyńska Grazyna, Kato Haru, Reijans Martin, Meisel-Mikołajczyk Felicja, Łuczak Mirosław, van Belkum Alex

机构信息

Department of Medical Microbiology, Medical University of Warsaw, Chalubinski Street, 02-004 Warsaw, Poland.

出版信息

J Clin Microbiol. 2007 May;45(5):1607-10. doi: 10.1128/JCM.00306-07. Epub 2007 Feb 21.

DOI:10.1128/JCM.00306-07
PMID:17314219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1865912/
Abstract

Amplified fragment length polymorphism genotypes, antibiotic resistance profiles, and toxin profiles of Clostridium difficile strains from Warsaw were determined. The isolates segregate in six major genotypes, coinciding with toxin profiles. Most of the toxin A-negative toxin B-positive toxin CDT-negative strains possess ermB, and several strains were resistant to fluoroquinolones. Resistograms and toxin types of C. difficile strains are epidemicity determinants.

摘要

测定了来自华沙的艰难梭菌菌株的扩增片段长度多态性基因型、抗生素耐药谱和毒素谱。分离株分为六种主要基因型，与毒素谱一致。大多数毒素A阴性、毒素B阳性、二元毒素（CDT）阴性的菌株携带ermB，并且有几种菌株对氟喹诺酮类耐药。艰难梭菌菌株的耐药谱和毒素类型是流行的决定因素。

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2
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Emerg Infect Dis. 2006 Mar;12(3):409-15. doi: 10.3201/eid1205.051064.
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