Denkers Eric Y, Butcher Barbara A
Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853-6401, USA.
Trends Parasitol. 2005 Jan;21(1):35-41. doi: 10.1016/j.pt.2004.10.004.
Macrophages are crucial in immunity to infection. They possess potent antimicrobial function, and efficiently process and present peptide antigens for T-cell activation. Despite this, the intracellular protozoan parasites Toxoplasma gondii, Trypanosoma cruzi and Leishmania spp. target macrophages for infection. Each has adopted unique strategies to subvert macrophage antimicrobial functions. The parasites sabotage killing activities through sophisticated manipulation of intracellular macrophage signaling pathways. These subversive activities are probably dictated by the need to evade microbicidal effector function, as well as to avoid proinflammatory pathology that can destabilize the host-parasite interaction. The molecular details of how intracellular protozoans manipulate macrophage signal transduction pathways for their own ends are beginning to emerge.
巨噬细胞在抗感染免疫中至关重要。它们具有强大的抗菌功能，能有效地处理和呈递肽抗原以激活T细胞。尽管如此，细胞内原生动物寄生虫弓形虫、克氏锥虫和利什曼原虫属仍将巨噬细胞作为感染目标。每种寄生虫都采用了独特的策略来破坏巨噬细胞的抗菌功能。这些寄生虫通过巧妙地操纵细胞内巨噬细胞信号通路来破坏杀伤活性。这些破坏活动可能是出于逃避杀菌效应功能以及避免引发可能破坏宿主 - 寄生虫相互作用的促炎病理反应的需要。细胞内原生动物如何为自身目的操纵巨噬细胞信号转导通路的分子细节正开始显现出来。
