Goetz C G, Tanner C M, Stebbins G T, Leipzig G, Carr W C
Department of Neurological Sciences, Rush Presbyterian St. Luke's Medical Center, Chicago, IL 60612.
Neurology. 1992 Apr;42(4):784-8. doi: 10.1212/wnl.42.4.784.
We studied 58 adults with Gilles de la Tourette's syndrome diagnosed during childhood. Tics persisted in all patients but were moderate/severe in only 24%, compared with 60% at the time of worst function. Coprolalia persisted in 4%, compared with 22% at the time of worst function. For most patients, worst function occurred in adolescence (mode = 13 years). In spite of a high frequency of school and behavioral problems during development, 98% graduated high school and 90% were full-time students or fully employed. Features predictive of mild tic severity in adulthood were mild tics during the patient's worst pre-adulthood function and mild tics during early and late adolescence. Childhood tic severity had no predictive value, and likewise, coprolalia during development did not increase the risk for adult moderate/severe tics.
我们研究了58名童年期被诊断为抽动秽语综合征的成年人。所有患者的抽动症状均持续存在，但只有24%的患者症状为中度/重度，而在功能最差时这一比例为60%。秽语症的持续存在率为4%，而在功能最差时为22%。对于大多数患者来说，功能最差的时期出现在青春期（众数为13岁）。尽管在发育过程中学校和行为问题频发，但98%的患者高中毕业，90%为全日制学生或有全职工作。成年期抽动症状较轻的预测因素是患者成年前功能最差时抽动症状较轻以及青春期早期和晚期抽动症状较轻。童年期抽动症状的严重程度没有预测价值，同样，发育过程中的秽语症也不会增加成年期出现中度/重度抽动症状的风险。
