Klawans H L, Barr A
Arch Neurol. 1985 Nov;42(11):1079-80. doi: 10.1001/archneur.1985.04060100061023.
In contrast to the lifelong persistence of symptoms characteristic of Gilles de la Tourette's syndrome, multiple tic of childhood is considered to be a self-limited disorder that remits by early adulthood. We describe four patients who had a history of multiple tic of childhood, complete absence of tics throughout most of their adult lives, and recurrence of tics in late adult life. All four had multiple tics that began before the age of 9 years and included both motor and vocal tics that changed in location and severity over time. None of the patients exhibited coprolalia. All tics subsided before the age of 20 years, only to recur after the age of 60 years, once again including both motor and vocal tics that changed in location and severity slowly over time. The one patient who was severely bothered by the recurrence of motor and vocal tics responded well to haloperidol. Although they do not fit into any accepted diagnostic category for multiple tic, these patients suggest that multiple tic of childhood can recur in adult life. This suggests that Gilles de la Tourette's syndrome may be a continuum for chronic multiple tic of childhood to full-blown classic Gilles de la Tourette's syndrome.
与抽动秽语综合征症状终身持续的特点不同，儿童多发性抽动被认为是一种自限性疾病，到成年早期会自行缓解。我们描述了四名患者，他们有儿童多发性抽动病史，成年后的大部分时间里抽动完全消失，但在成年后期抽动又复发。这四名患者的多发性抽动均始于9岁之前，包括运动性和发声性抽动，其部位和严重程度随时间变化。所有患者均未出现秽语症。所有抽动在20岁之前都已消退，但在60岁之后再次出现，同样包括运动性和发声性抽动，其部位和严重程度随时间缓慢变化。其中一名因运动性和发声性抽动复发而深受困扰的患者，使用氟哌啶醇治疗效果良好。尽管这些患者不符合任何已被认可的儿童多发性抽动诊断类别，但他们表明儿童多发性抽动在成年期可能会复发。这表明抽动秽语综合征可能是从儿童慢性多发性抽动到典型的全面性抽动秽语综合征的一个连续谱。
