Gonenne J, Castillo E J, Camilleri M, Burton D, Thomforde G M, Baxter K L, Zinsmeister A R
Clinical Enteric Neuroscience Translational and Epidemiological Research Program, Gastroenterology Research Unit, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
Neurogastroenterol Motil. 2005 Feb;17(1):44-50. doi: 10.1111/j.1365-2982.2004.00588.x.
Nutrient drink tests have been proposed as a surrogate for measurement of gastric accommodation. To study the relationship of maximum tolerated volume (MTV) during nutrient drink test and gastric volumes measured by single-photon emission computed tomography (SPECT) in healthy controls and functional dyspepsia (FD) patients. We reviewed data from 85 healthy controls and 35 FD residents of south-eastern Minnesota. All underwent standardized nutrient drink and SPECT studies between August 2000 and June 2003. To test for associations between nutrient drink test and SPECT gastric volumes, we used multiple linear regression and partial regression analyses, assigning age, gender, dyspepsia status and postprandial symptoms as covariates in the model. In the combined group (healthy and FD), MTV was weakly associated with fasting gastric volume (r = 0.43, P = 0.0001) and with volume response to feeding (r = 0.25, P = 0.006). In the FD group, associations were similar (fasting r = 0.53, P = 0.001; postmeal r = 0.32, P = 0.06). After accounting for covariates, MTV only explained 13 and 3% of variations in fasting and postprandial volumes measured by SPECT. MTV during the nutrient drink test does not accurately reflect gastric volume measurements by SPECT in healthy controls and a sample of people in the community with FD.
营养饮料测试已被提议作为测量胃容纳功能的替代方法。为研究健康对照者和功能性消化不良（FD）患者在营养饮料测试中的最大耐受量（MTV）与通过单光子发射计算机断层扫描（SPECT）测量的胃容量之间的关系。我们回顾了明尼苏达州东南部85名健康对照者和35名FD患者的数据。所有研究对象在2000年8月至2003年6月期间均接受了标准化的营养饮料和SPECT研究。为了测试营养饮料测试与SPECT胃容量之间的关联，我们使用了多元线性回归和偏回归分析，并将年龄、性别、消化不良状态和餐后症状作为模型中的协变量。在合并组（健康者和FD患者）中，MTV与空腹胃容量弱相关（r = 0.43，P = 0.0001），与进食后的容量反应也弱相关（r = 0.25，P = 0.006）。在FD组中，关联情况相似（空腹r = 0.53，P = 0.001；餐后r = 0.32，P = 0.06）。在考虑协变量后，MTV仅解释了SPECT测量的空腹和餐后胃容量变化的13%和3%。在健康对照者和社区中患有FD的人群样本中，营养饮料测试期间的MTV不能准确反映通过SPECT测量的胃容量。
