Wyrzykiewicz Elzbieta, Wendzonka Monika, Kedzia Bogdan
Faculty of Chemistry, Adam Mickiewicz University, Poznań, Poland.
Eur J Med Chem. 2006 Apr;41(4):519-25. doi: 10.1016/j.ejmech.2005.11.010. Epub 2006 Mar 3.
The synthesis of twenty-one new (E)-4-[piperidino-(4;-methylpiperidino-, morpholino-)N-alkoxy] stilbenes is reported. The compounds were tested for antimicrobial activities against Gram-negative, Gram-positive bacteria, and fungi. In particular, compounds 3b, 3c, 3f, 3g, 3h, 3k, 3l showed good antibacterial activity against Staphylococcus aureus and 3h, 3k, 3m, 3n also against Bacillus subtilis, as well as 3h, 3n also against Streptococcus faecalis.
报道了21种新的（E）-4-[哌啶基-（4'-甲基哌啶基-、吗啉基-）N-烷氧基]芪的合成。测试了这些化合物对革兰氏阴性菌、革兰氏阳性菌和真菌的抗菌活性。特别是，化合物3b、3c、3f、3g、3h、3k、3l对金黄色葡萄球菌显示出良好的抗菌活性，3h、3k、3m、3n对枯草芽孢杆菌也有抗菌活性，3h、3n对粪肠球菌也有抗菌活性。
