韩国活禽市场中的禽流感病毒及其致病潜力。
Avian influenza viruses in Korean live poultry markets and their pathogenic potential.
作者信息
Choi Young Ki, Seo Sang Heui, Kim Jin A, Webby Richard J, Webster Robert G
机构信息
Division of Virology, Department of Infectious Diseases, Mail Stop 330, St. Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis TN 38105-2794, USA.
出版信息
Virology. 2005 Feb 20;332(2):529-37. doi: 10.1016/j.virol.2004.12.002.
We surveyed live-poultry markets in Korea in 2003 and isolated 9 H9N2, 6 H3N2, and 1 H6N1 influenza viruses. Antigenic and phylogenetic analyses showed that all 9 H9N2 isolates were of A/Chicken/Korea/25232-96006/96-like lineage (which caused disease in chickens in Korea in 1996) but were different from H9N2 viruses of southeastern China. They had at least 4 genotypes and replicated in chickens but not in mice. The H3N2 and H6N1 viruses were new to Korea and were probably reassortants of avian influenza viruses from southeastern China and recent Korean H9N2 viruses. All 8 segments of the H3N2 viruses formed a single phylogenetic cluster with 99.1 to 100% homology. The H3N2 viruses replicated in chickens and mice without preadaptation, but the H6N1 virus did not. Our results show an increasingly diverse pool of avian influenza viruses in Korea that are potential pandemic influenza agents.
2003年，我们对韩国的活禽市场进行了调查，分离出9株H9N2、6株H3N2和1株H6N1流感病毒。抗原性和系统发育分析表明，所有9株H9N2分离株均属于A/Chicken/Korea/25232 - 96006/96样谱系（该谱系在1996年曾在韩国鸡群中引发疾病），但与中国东南部的H9N2病毒不同。它们至少有4种基因型，能在鸡体内复制，但不能在小鼠体内复制。H3N2和H6N1病毒对韩国来说是新出现的，可能是中国东南部禽流感病毒与韩国近期H9N2病毒的重组体。H3N2病毒的所有8个基因片段形成了一个单一的系统发育簇，同源性为99.1%至100%。H3N2病毒无需预先适应就能在鸡和小鼠体内复制，但H6N1病毒不能。我们的研究结果表明，韩国的禽流感病毒种类日益多样，这些病毒都是潜在的大流行性流感病原体。
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