Wu Wenlin, Wang Lei, Zhang Xiaobo
School of Life Sciences, Xiamen University, Xiamen 361005, The People's Republic of China.
Virology. 2005 Feb 20;332(2):578-83. doi: 10.1016/j.virol.2004.12.011.
White spot syndrome virus (WSSV) is a major shrimp pathogen causing large economic losses. In an attempt to identify the envelope proteins involved in virus infection, antisera against six WSSV envelope proteins were used in neutralization assays conducted in vivo. The results showed that the virus infection could be significantly delayed or neutralized by antibodies against three WSSV envelope proteins (VP68, VP281 and VP466). This neutralization was further confirmed by quantitative PCR. It could be concluded that the viral envelope proteins VP68, VP281 and VP466 played roles in WSSV infection to shrimp.
白斑综合征病毒（WSSV）是一种导致巨大经济损失的主要对虾病原体。为了鉴定参与病毒感染的包膜蛋白，针对六种WSSV包膜蛋白的抗血清被用于体内中和试验。结果表明，针对三种WSSV包膜蛋白（VP68、VP281和VP466）的抗体能够显著延迟或中和病毒感染。这种中和作用通过定量PCR得到进一步证实。可以得出结论，病毒包膜蛋白VP68、VP281和VP466在WSSV感染对虾的过程中发挥了作用。
