Laras Kanti, Sukri Nono C, Larasati Ria P, Bangs Michael J, Kosim Rizal, Wandra Tony, Master John, Kosasih Herman, Hartati Sri, Beckett Charmagne, Sedyaningsih Endang R, Beecham H James, Corwin Andrew L
US Naval Medical Research Unit No. 2 (US NAMRU-2), Box 3, Unit 8132, Jakarta, Indonesia.
Trans R Soc Trop Med Hyg. 2005 Feb;99(2):128-41. doi: 10.1016/j.trstmh.2004.03.013.
Twenty-four distinct outbreaks of probable chikungunya (CHIK) etiology were identified throughout Indonesia from September 2001 to March 2003, after a near 20-year hiatus of epidemic CHIK activity in the country. Thirteen outbreak reports were based on clinical observations alone, and 11 confirmed by serological/virological methods. Detailed epidemiological profiles of two investigated outbreaks in Bogor and Bekasi are presented. Human sera were screened using an ELISA for IgM and IgG anti-CHIK antibodies. Additionally, reverse transcriptase PCR and virus isolation were attempted for virus identification. The mean age of cases was 37 +/- 18 years in Bogor and 33 +/- 20 years in Bekasi. There was no outstanding case-clustering, although outbreak-affected households were observed to be geographically grouped within villages. The attack rates in Bogor and Bekasi were 2.8/1000 and 6.7/1000 inhabitants respectively. Both outbreaks started in the rainy season following increased Aedes aegypti and A. albopictus densities.
2001年9月至2003年3月期间，在印度尼西亚全国范围内确认了24起可能由基孔肯雅热（CHIK）病因引起的不同疫情，该国此前近20年未出现过基孔肯雅热的流行活动。13份疫情报告仅基于临床观察，11份经血清学/病毒学方法确认。文中呈现了在茂物和勿加泗调查的两起疫情的详细流行病学概况。使用酶联免疫吸附测定法（ELISA）对人体血清进行IgM和IgG抗基孔肯雅热抗体筛查。此外，尝试通过逆转录聚合酶链反应（RT-PCR）和病毒分离进行病毒鉴定。茂物病例的平均年龄为37±18岁，勿加泗为33±20岁。虽然观察到受疫情影响的家庭在村庄内按地理位置聚集，但没有明显的病例聚集现象。茂物和勿加泗的发病率分别为2.8/1000和6.7/1000居民。两起疫情均在埃及伊蚊和白纹伊蚊密度增加后的雨季开始。
