在初期亚临床结核病期间被抗体识别的结核分枝杆菌抗原。
Antigens of Mycobacterium tuberculosis recognized by antibodies during incipient, subclinical tuberculosis.
作者信息
Singh Krishna K, Dong Yuxin, Belisle John T, Harder Jeffrey, Arora Vijay K, Laal Suman
机构信息
Department of Pathology, New York University School of Medicine, New York, New York, USA.
出版信息
Clin Diagn Lab Immunol. 2005 Feb;12(2):354-8. doi: 10.1128/CDLI.12.2.354-358.2005.
Abstract
Serum samples obtained from human immunodeficiency virus (HIV)-infected tuberculosis (TB) patients months prior to clinical TB were used to delineate the profile of Mycobacterium tuberculosis culture filtrate proteins recognized during subclinical TB. A subset of approximately 12 antigens was recognized by antibodies in these serum samples. Antibodies to two of these antigens (81 [88]-kDa malate synthase [GlcB] and MPT51) were present in serum samples obtained during incipient subclinical TB in 19 (approximately 90%) of the 21 HIV-infected TB patients tested. These antigens will be useful for devising diagnostic tests that can identify HIV-positive individuals who are at a high risk for developing clinical TB.
摘要
从人类免疫缺陷病毒（HIV）感染的结核病（TB）患者临床结核病出现前数月采集的血清样本，用于描绘亚临床结核病期间所识别的结核分枝杆菌培养滤液蛋白谱。这些血清样本中的抗体识别出约12种抗原的一个子集。在接受检测的21名HIV感染的TB患者中，19名（约90%）在初期亚临床结核病期间采集的血清样本中存在针对其中两种抗原（81[88]kDa苹果酸合酶[GlcB]和MPT51）的抗体。这些抗原将有助于设计诊断测试，以识别有发展为临床结核病高风险的HIV阳性个体。
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