Singh Archana, Singh Dheeraj K, Kharwar Ravindra N, White James F, Gond Surendra K
Department of Botany, MMV, Banaras Hindu University, Varanasi 221005, India.
Department of Botany, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Microorganisms. 2021 Jan 19;9(1):197. doi: 10.3390/microorganisms9010197.
Fungal endophytes are well-established sources of biologically active natural compounds with many producing pharmacologically valuable specific plant-derived products. This review details typical plant-derived medicinal compounds of several classes, including alkaloids, coumarins, flavonoids, glycosides, lignans, phenylpropanoids, quinones, saponins, terpenoids, and xanthones that are produced by endophytic fungi. This review covers the studies carried out since the first report of taxol biosynthesis by endophytic in 1993 up to mid-2020. The article also highlights the prospects of endophyte-dependent biosynthesis of such plant-derived pharmacologically active compounds and the bottlenecks in the commercialization of this novel approach in the area of drug discovery. After recent updates in the field of 'omics' and 'one strain many compounds' (OSMAC) approach, fungal endophytes have emerged as strong unconventional source of such prized products.
真菌内生菌是生物活性天然化合物的成熟来源，许多内生菌能产生具有药理学价值的特定植物衍生产品。本综述详细介绍了几类典型的植物衍生药用化合物，包括生物碱、香豆素、黄酮类化合物、糖苷、木脂素、苯丙素类、醌类、皂苷、萜类化合物和呫吨酮，这些都是由内生真菌产生的。本综述涵盖了自1993年内生菌首次报道紫杉醇生物合成至2020年年中所开展的研究。本文还强调了依赖内生菌生物合成此类植物衍生药理活性化合物的前景以及这种新方法在药物发现领域商业化过程中的瓶颈。在“组学”和“一株多化合物”（OSMAC）方法领域最近取得进展之后，真菌内生菌已成为此类珍贵产品强大的非传统来源。
