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重组白细胞介素-1α、白细胞介素-2和巨噬细胞集落刺激因子-1可提高腹腔接种致死剂量单纯疱疹病毒-1的新生C57BL/6小鼠的存活率。

Recombinant interleukin-1 alpha, interleukin-2 and M-CSF-1 enhance the survival of newborn C57BL/6 mice inoculated intraperitoneally with a lethal dose of herpes simplex virus-1.

作者信息

Berkowitz C, Becker Y

机构信息

Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Israel.

出版信息

Arch Virol. 1992;124(1-2):83-93. doi: 10.1007/BF01314627.

DOI:10.1007/BF01314627
PMID:1571022
Abstract

Recombinant Interleukin-1 alpha (IL-1 alpha), Interleukin-2 (IL-2) and recombinant macrophage colony-stimulating factor-1 (M-CSF-1) as well as combinations of IL-2 and M-CSF-1 were studied for their ability to protect seven-day-old C57BL/6 mice against HSV-1 infection. Treatment of the mice with IL-2, M-CSF-1 or combinations of IL-2 and M-CSF-1 significantly increased survival rates. Treatment with IL-1 alpha (10 U and 100 U/mouse) was most effective in protection against HSV-1, resulting in significantly increased survival rates more than four times greater than the survival rate of the infected control group.

摘要

研究了重组白细胞介素-1α（IL-1α）、白细胞介素-2（IL-2）和重组巨噬细胞集落刺激因子-1（M-CSF-1）以及IL-2和M-CSF-1的组合对7日龄C57BL/6小鼠抵抗单纯疱疹病毒1型（HSV-1）感染的保护能力。用IL-2、M-CSF-1或IL-2与M-CSF-1组合治疗小鼠可显著提高存活率。用IL-1α（10 U和100 U/小鼠）治疗对HSV-1的保护最有效，导致存活率显著提高，比感染对照组的存活率高出四倍多。

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Recombinant interleukin-1 alpha, interleukin-2 and M-CSF-1 enhance the survival of newborn C57BL/6 mice inoculated intraperitoneally with a lethal dose of herpes simplex virus-1.重组白细胞介素-1α、白细胞介素-2和巨噬细胞集落刺激因子-1可提高腹腔接种致死剂量单纯疱疹病毒-1的新生C57BL/6小鼠的存活率。
Arch Virol. 1992;124(1-2):83-93. doi: 10.1007/BF01314627.
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本文引用的文献

1
Determinants of protection by human immune globulin against experimental herpes neonatorum.人免疫球蛋白对实验性新生儿疱疹的保护作用的决定因素。
Proc Soc Exp Biol Med. 1982 Jul;170(3):291-7. doi: 10.3181/00379727-170-41433.
2
Site-specific mutagenesis of the human interleukin-2 gene: structure-function analysis of the cysteine residues.人白细胞介素-2基因的位点特异性诱变：半胱氨酸残基的结构-功能分析
Science. 1984 Jun 29;224(4656):1431-3. doi: 10.1126/science.6427925.
3
Interleukin-1.白细胞介素-1
The antiviral activity of tumour necrosis factor on herpes simplex virus type 1: role for a butylated hydroxyanisole sensitive factor.
肿瘤坏死因子对1型单纯疱疹病毒的抗病毒活性：丁基化羟基茴香醚敏感因子的作用。
Arch Virol. 1995;140(4):703-19. doi: 10.1007/BF01309959.
4
An analysis of the role of skin Langerhans cells (LC) in the cytoplasmic processing of HIV-1 peptides after "peplotion" transepidermal transfer and HLA class I presentation to CD8+ CTLs--an approach to immunization of humans.“包膜化”经表皮转移后皮肤朗格汉斯细胞（LC）在HIV-1肽胞质加工及HLA I类分子向CD8+ 细胞毒性T淋巴细胞呈递中的作用分析——一种人类免疫方法
Virus Genes. 1995 Jan;9(2):133-47. doi: 10.1007/BF01702656.
5
Enhancement by TNF-alpha of reactivation and replication of latent herpes simplex virus from trigeminal ganglia of mice.肿瘤坏死因子-α增强小鼠三叉神经节中潜伏单纯疱疹病毒的重新激活和复制
Arch Virol. 1995;140(6):987-92. doi: 10.1007/BF01315409.
Rev Infect Dis. 1984 Jan-Feb;6(1):51-95. doi: 10.1093/clinids/6.1.51.
4
Biological activity of recombinant human interleukin-2 produced in Escherichia coli.在大肠杆菌中产生的重组人白细胞介素-2的生物活性。
Science. 1984 Mar 30;223(4643):1412-4. doi: 10.1126/science.6367046.
5
Ontogeny of murine cellular cytotoxicity to herpes simplex virus-infected cells.小鼠对单纯疱疹病毒感染细胞的细胞毒性个体发生。
Infect Immun. 1980 Dec;30(3):847-50. doi: 10.1128/iai.30.3.847-850.1980.
6
Cloning and expression of murine interleukin-1 cDNA in Escherichia coli.小鼠白细胞介素-1 cDNA在大肠杆菌中的克隆与表达。
Nature. 1984;312(5993):458-62. doi: 10.1038/312458a0.
7
Experimental infection of inbred mice with herpes simplex virus. III. Comparison between newborn and adult C57BL/6 mice.单纯疱疹病毒对近交系小鼠的实验性感染。III. 新生与成年C57BL/6小鼠的比较
J Gen Virol. 1982 May;60(Pt 1):25-9. doi: 10.1099/0022-1317-60-1-25.
8
Analysis in human neonates of defective antibody-dependent cellular cytotoxicity and natural killer cytotoxicity to herpes simplex virus-infected cells.对人类新生儿针对单纯疱疹病毒感染细胞的缺陷性抗体依赖性细胞毒性和自然杀伤细胞毒性的分析。
J Infect Dis. 1984 Jul;150(1):14-9. doi: 10.1093/infdis/150.1.14.
9
Selective effects of anti-macrophage serum, silica and anti-lymphocyte serum on pathogenesis of herpes virus infection of young adult mice.抗巨噬细胞血清、二氧化硅和抗淋巴细胞血清对成年小鼠疱疹病毒感染发病机制的选择性作用。
J Immunol. 1970 May;104(5):1155-9.
10
Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells.γ干扰素诱导的人白血病及正常单核细胞中白细胞介素2受体的表达及白细胞介素2的结合
J Exp Med. 1985 Sep 1;162(3):1111-6. doi: 10.1084/jem.162.3.1111.