Janszky I, Ericson M, Blom M, Georgiades A, Magnusson J-O, Alinagizadeh H, Ahnve S
Preventive Medicine, Department of Public Health Sciences, Karolinska Institute, and Centre of Public Health, Stockholm County Council, Stockholm, Sweden.
Heart. 2005 Mar;91(3):314-8. doi: 10.1136/hrt.2004.035105.
To test the hypothesis that alcohol consumption is positively related to heart rate variability (HRV) in women with coronary heart disease (CHD) and therefore that cardiac autonomic activity is potentially implicated in the mediation of the favourable effects of moderate drinking.
DESIGN, SETTINGS, AND PATIENTS: Cross sectional study of female patients who survived hospitalisation for acute myocardial infarction or underwent a revascularisation procedure, percutaneous transluminal coronary angioplasty, or coronary artery bypass grafting.
Ambulatory 24 hour ECG was recorded during normal activities. The mean of the standard deviations of all normal to normal intervals for all five minute segments of the entire recording (SDNNI) and the following frequency domain parameters were assessed: total power, high frequency power, low frequency power, and very low frequency power. A standardised questionnaire evaluated self reported consumption of individual alcoholic beverage types: beer, wine, and spirits. Other clinical characteristics, such as age, body mass index, smoking habits, history of diabetes mellitus, menopausal status, educational status, and treatment, were also assessed.
Wine intake was associated with increased HRV in both time and frequency domains independently of other clinical covariates (for example, ln SDNNI was 3.89 among wine drinkers v 3.59 among wine non-drinkers in the multivariate model; p = 0.014). In contrast, consumption of beer and spirits and the total amount of alcohol consumed did not relate significantly to any of the HRV parameters.
Intake of wine, but not of spirits or beer, is positively and independently associated with HRV in women with CHD. These results may contribute to the understanding of the complex relation between alcohol consumption and CHD.
检验以下假设：冠心病（CHD）女性的酒精摄入量与心率变异性（HRV）呈正相关，因此心脏自主神经活动可能参与了适度饮酒的有益作用的介导过程。
设计、设置和患者：对因急性心肌梗死住院存活或接受血管重建手术（经皮腔内冠状动脉成形术或冠状动脉旁路移植术）的女性患者进行横断面研究。
在正常活动期间记录24小时动态心电图。评估整个记录中所有五分钟片段的所有正常到正常间期标准差的平均值（SDNNI）以及以下频域参数：总功率、高频功率、低频功率和极低频功率。通过标准化问卷评估自我报告的各类酒精饮料（啤酒、葡萄酒和烈酒）的摄入量。还评估了其他临床特征，如年龄、体重指数、吸烟习惯、糖尿病史、绝经状态、教育程度和治疗情况。
葡萄酒摄入量在时域和频域均与HRV增加相关，且独立于其他临床协变量（例如，在多变量模型中，葡萄酒饮用者的ln SDNNI为3.89，非葡萄酒饮用者为3.59；p = 0.014）。相比之下，啤酒和烈酒的摄入量以及酒精总摄入量与任何HRV参数均无显著关联。
在患有CHD的女性中，葡萄酒的摄入量与HRV呈正相关且独立相关，而烈酒或啤酒则不然。这些结果可能有助于理解酒精消费与CHD之间的复杂关系。
