Ma Wenzhe, Huang Yicun, Lin Lidong, Zhu Xiaofeng, Chen Yizhu, Xu Hanhong, Wei Xiaoyi
South China Botanical Garden, Chinese Academy of Sciences, Leyiju, Guangzhou 510650, China.
J Antibiot (Tokyo). 2004 Nov;57(11):721-5. doi: 10.7164/antibiotics.57.721.
Two new illudane sesquiterpenes, paneolic acid and paneolilludinic acid, along with a known antibiotic diterpene, pleuromutilin, were isolated from the mycelial solid cultures of Panaeolus retirugis. Their structures were elucidated on the basis of spectroscopic analysis. Both compounds exhibited antibacterial activity against Staphylococcus aureus, and paneolic acid showed cytotoxicity to HL60 cell with an IC50 of 18.9 microg/ml.
从皱盖球盖菇的菌丝体固体培养物中分离出两种新的榄烷倍半萜类化合物——盘菌酸和盘菌榄烷酸，以及一种已知的抗生素二萜类化合物——截短侧耳素。通过光谱分析确定了它们的结构。这两种化合物均对金黄色葡萄球菌表现出抗菌活性，且盘菌酸对HL60细胞具有细胞毒性，IC50为18.9微克/毫升。
