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来自内生地衣真菌山茱萸隐小菇的具有抗神经炎症活性的结构多样的倍半萜类化合物。

Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae.

作者信息

Zhai Yi-Jie, Li Jian-Nan, Gao Yu-Qi, Gao Lin-Lin, Wang Da-Cheng, Han Wen-Bo, Gao Jin-Ming

机构信息

Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2021 Jun;11(3):325-332. doi: 10.1007/s13659-021-00299-9. Epub 2021 May 7.

DOI:10.1007/s13659-021-00299-9
PMID:33963522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8141073/
Abstract

Two new sterpurane sesquiterpenoids named sterpurol D (1) and sterpurol E (2), and one skeletally new sesquiterpene, cryptomaraone (3), bearing a 5,6-fused bicyclic ring system, along with five known ones, sterpurol A (4), sterpurol B (5), paneolilludinic Acid (6), murolane-2α, 9β-diol-3-ene (7) and (-)-10,11-dihydroxyfarnesol (8) were isolated from an endolichenic fungus Cryptomarasmius aucubae. The structures of the new compounds were elucidated by analysis of NMR spectroscopic spectra and HRESIMS data. The absolute configurations of 1 and 2 were established by spectroscopic data analysis and comparison of specific optical rotation, as well as the biosynthetic consideration. Additionally, compounds 1, 2, 4-6, and 8 showed significant nitric oxide (NO) production inhibition in Lipopolysaccharide (LPS)-induced BV-2 microglial cells with the IC values ranging from 9.06 to 14.81 μM.

摘要

从内生地衣真菌日本珊瑚状隐孔菌（Cryptomarasmius aucubae）中分离出两种新的紫罗烷倍半萜类化合物，分别命名为紫罗醇D（1）和紫罗醇E（2），以及一种骨架新颖的倍半萜，隐马腊酮（3），其带有一个5,6-稠合的双环系统，还有五种已知化合物，紫罗醇A（4）、紫罗醇B（5）、泛裸盖菌素酸（6）、莫罗烷-2α,9β-二醇-3-烯（7）和（-）-10,11-二羟基法尼醇（8）。通过对核磁共振光谱和高分辨电喷雾电离质谱数据的分析阐明了新化合物的结构。通过光谱数据分析、比旋光度比较以及生物合成方面的考虑确定了1和2的绝对构型。此外，化合物1、2、4-6和8在脂多糖（LPS）诱导的BV-2小胶质细胞中显示出显著的一氧化氮（NO）生成抑制作用，IC值范围为9.06至14.81 μM。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bca/8141073/22af41a94e5b/13659_2021_299_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bca/8141073/958d83caf489/13659_2021_299_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bca/8141073/22af41a94e5b/13659_2021_299_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bca/8141073/958d83caf489/13659_2021_299_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8bca/8141073/22af41a94e5b/13659_2021_299_Fig2_HTML.jpg

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