Kojima Masayo, Wakai Kenji, Tokudome Shinkan, Suzuki Koji, Tamakoshi Koji, Watanabe Yoshiyuki, Kawado Miyuki, Hashimoto Shuji, Hayakawa Norihiko, Ozasa Kotaro, Toyoshima Hideaki, Suzuki Sadao, Ito Yoshinori, Tamakoshi Akiko
Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Am J Epidemiol. 2005 Mar 1;161(5):462-71. doi: 10.1093/aje/kwi066.
To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80 degrees C until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total omega-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), alpha-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of omega-6 polyunsaturated fatty acids on colorectal cancer risk were detected.
为研究血清脂肪酸与结直肠癌风险之间的关系，作者开展了一项巢式病例对照研究，该研究作为日本协作队列研究的一部分，纳入了169例结直肠癌病例和481例按年龄和登记地区匹配的对照。血清样本由受试者在基线时（1988年至1990年之间）捐赠，并在-80摄氏度下储存至2002年。采用气相色谱法测量血清脂肪酸水平，并以总脂质的重量百分比表示。经生活方式因素调整的条件逻辑回归分析显示，男性中，总ω-3多不饱和脂肪酸（比值比=0.24，95%置信区间：0.08，0.76）、α-亚麻酸（比值比=0.39，95%置信区间：0.16，0.91）、二十二碳五烯酸（比值比=0.30，95%置信区间：0.11，0.80）和二十二碳六烯酸（比值比=0.23，95%置信区间：0.07，0.76）在最高四分位数水平与最低四分位数水平相比时，结直肠癌风险均显著降低。对于女性，虽然二十二碳五烯酸与结直肠癌风险之间观察到微弱的负相关，但无统计学意义。未检测到高血清水平的ω-6多不饱和脂肪酸对结直肠癌风险有不良影响。
