一种葡萄糖感应隐形眼镜：从实验室到患者
A glucose-sensing contact lens: from bench top to patient.
作者信息
Badugu Ramachandram, Lakowicz Joseph R, Geddes Chris D
机构信息
Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.
出版信息
Curr Opin Biotechnol. 2005 Feb;16(1):100-7. doi: 10.1016/j.copbio.2004.12.007.
Abstract
In the past few years we have seen the development of several new technologies for the continuous and non-invasive monitoring of physiological glucose, such as the GlucoWatch, glucose-sensing skin patches and approaches based on a glucose-sensing tattoo. One approach that differs from current thinking is based on the determination and monitoring of tear glucose, which is well known to track blood glucose with an approximate 30 min lag time, using disposable and colorless contact lenses. These contact lenses can be worn by diabetics who can colorimetrically see changes in their contact lens color or other fluorescence-based properties, giving an indication of tear and blood glucose levels.
摘要
在过去几年中，我们看到了几种用于连续无创监测生理葡萄糖的新技术的发展，例如葡萄糖监测仪、葡萄糖感应皮肤贴片以及基于葡萄糖感应纹身的方法。一种与当前思路不同的方法是基于泪液葡萄糖的测定和监测，众所周知，泪液葡萄糖可追踪血糖，但存在约30分钟的滞后时间，使用一次性无色隐形眼镜即可实现。糖尿病患者可以佩戴这些隐形眼镜，通过比色法观察隐形眼镜颜色或其他基于荧光的特性变化，从而得知泪液和血糖水平。
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