使用单糖感应隐形眼镜对生理血糖进行无创连续监测。
Noninvasive continuous monitoring of physiological glucose using a monosaccharide-sensing contact lens.
作者信息
Badugu Ramachandram, Lakowicz Joseph R, Geddes Chris D
机构信息
Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, Medical Biotechnology Center, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.
出版信息
Anal Chem. 2004 Feb 1;76(3):610-8. doi: 10.1021/ac0303721.
We have tested the feasibility of tear glucose sensing using a daily, disposable contact lens embedded with boronic acid-containing fluorophores as a potential alternative to current invasive glucose-monitoring techniques. Our findings show that our approach may, indeed, be suitable for the continuous monitoring of tear glucose levels in the range 50-500 microM, which track blood glucose levels that are approximately 5-10-fold higher. We compare the response of the boronic acid probes in the contact lens to solution-based measurements and can conclude that both the pH and polarity within the contact lens need to be considered with respect to choosing/designing and optimizing glucose-sensing probes for contact lenses.
我们测试了使用一种每日更换的一次性隐形眼镜来检测泪液葡萄糖的可行性，该隐形眼镜嵌入了含硼酸的荧光团，作为当前侵入性葡萄糖监测技术的一种潜在替代方案。我们的研究结果表明，我们的方法确实可能适用于连续监测50 - 500微摩尔范围内的泪液葡萄糖水平，该范围可追踪大约高5 - 10倍的血糖水平。我们将隐形眼镜中硼酸探针的响应与基于溶液的测量进行了比较，可以得出结论，在选择/设计和优化用于隐形眼镜的葡萄糖传感探针时，需要考虑隐形眼镜内部的pH值和极性。
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