Odessey R
BioSurface Technology, Inc., Cambridge, Massachusetts.
J Burn Care Rehabil. 1992 Jan-Feb;13(1):174-80.
Since 1989 BioSurface Technology, Inc. (Cambridge, Mass.) has provided over 37,000 cultured epidermal autografts (CEAs) for more than 240 patients in 79 different burn centers in the United States and Europe. The average burn treated with BioSurface's CEA has been 70% total body surface area, half of that being full-thickness. Data, verified for 104 patients, indicate an average final "take" of about 60%, with half of all patients achieving a final take greater than or equal to 70% and 22% with final take greater than or equal to 90%. Sixteen percent of the patients had a take of less than 30%; many of these were associated with wound infection. Patient age, size of burn, and extent of full-thickness injury did not significantly affect take. Early excision followed by temporary coverage with homograft, which is allowed to engraft, was found to be associated with a low infection rate and a higher rate of CEA take. When engrafted homograft was only partially excised, leaving a layer of "allodermis" as the graft bed for CEA, take averaged 90% among 14 patients. Thus, our analysis of the extensive experience of many burn centers now permits more specific and helpful recommendations on standards of care to maximize efficacy of CEA.
自1989年以来，生物表面技术公司（位于马萨诸塞州剑桥市）已为美国和欧洲79个不同烧伤中心的240多名患者提供了超过37000块培养的自体表皮移植片（CEA）。接受该公司CEA治疗的烧伤患者平均烧伤面积达全身表面积的70%，其中一半为深度烧伤。对104名患者的数据验证表明，CEA平均最终“成活率”约为60%，所有患者中有一半的最终成活率大于或等于70%，22%的患者最终成活率大于或等于90%。16%的患者成活率低于30%；其中许多与伤口感染有关。患者年龄、烧伤面积和深度烧伤程度对成活率没有显著影响。早期切除后用同种异体皮临时覆盖并使其存活，被发现与低感染率和较高的CEA成活率相关。当仅部分切除存活的同种异体皮，留下一层“异体真皮”作为CEA的植皮床时，14名患者的平均成活率为90%。因此，我们对众多烧伤中心丰富经验的分析，现在可以就护理标准提出更具体、更有帮助的建议，以最大限度地提高CEA的疗效。
