脉搏波速度可预测心血管疾病死亡率：夏威夷-洛杉矶-广岛研究的结果
Pulse wave velocity predicts cardiovascular mortality: findings from the Hawaii-Los Angeles-Hiroshima study.
作者信息
Shokawa Tomoki, Imazu Michinori, Yamamoto Hideya, Toyofuku Mamoru, Tasaki Naohito, Okimoto Tomokazu, Yamane Kiminori, Kohno Nobuoki
机构信息
Department of Molecular and Internal Medicine, Graduate School of Biomedical Sciences, Hiroshima University, Japan.
出版信息
Circ J. 2005 Mar;69(3):259-64. doi: 10.1253/circj.69.259.
BACKGROUND
Arterial stiffness measurements, generally from pulse wave velocity (PWV), are widely used with little knowledge of their relationship to long-term cardiovascular mortality in general populations.
METHODS AND RESULTS
We studied a cohort of 492 Japanese-Americans living in Hawaii (mean age: 63.7 +/-8.8 years) to assess the relationship between PWV and cardiovascular disease mortality and all-cause mortality. During the 10-year follow-up, 43 patients died (14 from cardiovascular events). The cohort was divided into 2 groups by the cut-off value of PWV (9.9 m/s) represented in the receiver operating characteristic curve. The risk ratio for PWV values >9.9 m/s to all-cause mortality was 1.28 [95% confidence interval (CI): 1.14-1.42], and adjusted for other risk factors this ratio was 1.42 (95% CI: 0.96-2.11). The corresponding risk ratios for cardiovascular mortality was 4.46 (95% CI: 1.61-12.32) and 4.24 (95% CI: 1.39-12.96), respectively.
CONCLUSIONS
The present study demonstrated that an increased PWV value is associated with future cardiovascular disease death in Japanese-Americans living in Hawaii.
背景
动脉僵硬度测量，通常通过脉搏波速度（PWV）进行，在一般人群中广泛使用，但对其与长期心血管死亡率的关系了解甚少。
方法与结果
我们研究了492名居住在夏威夷的日裔美国人队列（平均年龄：63.7±8.8岁），以评估PWV与心血管疾病死亡率和全因死亡率之间的关系。在10年的随访期间，43名患者死亡（14例死于心血管事件）。根据受试者工作特征曲线中表示的PWV临界值（9.9米/秒），将该队列分为两组。PWV值>9.9米/秒与全因死亡率的风险比为1.28 [95%置信区间（CI）：1.14 - 1.42]，在调整其他风险因素后，该比值为1.42（95% CI：0.96 - 2.11）。心血管死亡率的相应风险比分别为4.46（95% CI：1.61 - 12.32）和4.24（95% CI：1.39 - 12.96）。
结论
本研究表明，PWV值升高与居住在夏威夷的日裔美国人未来心血管疾病死亡有关。
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