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关于舌蝇基因组计划的一个案例。

A case for a Glossina genome project.

作者信息

Aksoy Serap, Berriman Matt, Hall Neil, Hattori Masahira, Hide Winston, Lehane Michael J

机构信息

Yale University School of Medicine, 60 College Street, 606 LEPH, New Haven, CT 06520, USA.

出版信息

Trends Parasitol. 2005 Mar;21(3):107-11. doi: 10.1016/j.pt.2005.01.006.

Abstract

Given the medical and agricultural significance of Glossina, knowledge of the genomic aspects of the vector and vector-pathogen interactions are a high priority. In preparation for a full genome sequence initiative, an extensive set of expressed sequence tags (ESTs) has been generated from tissue-specific normalized libraries. In addition, bacterial artificial chromosome (BAC) libraries are being constructed, and information on the genome structure and size from different species has been obtained. An international consortium is now in place to further efforts to lead to a full genome project.

摘要

鉴于舌蝇在医学和农业方面的重要性,了解该媒介的基因组特征以及媒介与病原体的相互作用是当务之急。为启动全基因组测序计划做准备,已从组织特异性标准化文库中生成了大量表达序列标签(EST)。此外,正在构建细菌人工染色体(BAC)文库,并且已获得了不同物种的基因组结构和大小信息。目前,一个国际联盟已成立,旨在进一步推动全基因组计划的实施。

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