特应性哮喘与I型人类嗜T淋巴细胞病毒（HTLV-I）感染的矛盾共存：一例报告

Paradoxical coexistence of atopic asthma and Human T-Lymphotropic Virus Type I (HTLV-I) infection: a case report.

作者信息

Souza-Machado A, Cruz A A, Galvão T Sena, Muniz André, Porto A, Braga S, Carvalho E Marcelino

机构信息

Center for Respiratory Diseases, Federal University of Bahia, Salvador, Bahia, Brazil.

出版信息

J Investig Allergol Clin Immunol. 2004;14(4):348-51.

PMID:15736723

Abstract

In this case report, the authors report the presence of two supposedly antagonic immune diseases in the same patient. The patient is a 45-year-old white woman with a history of asthma and allergic rhinitis for the last 10 years. Asthmatic symptoms were present and were triggered after exposure to dust and mold. Her Human T-Lymphotropic Virus Type I (HTLV-I) seropositive status was detected by chance five years ago during a routine screening for blood donation. Skin prick tests were positive for Dermatophagoides pteronyssinus, Dermatophagoides farinae and Blomia tropicalis. Cytokine levels in unstimulated cultures were: IFNgamma= 1195 pg/ ml, TNFalpha = 460 pg/ml, IL5 = 41 pg/ml and IL10 = 265 pg/ml.

摘要

在本病例报告中，作者报告了同一患者体内存在两种看似相互拮抗的免疫疾病。该患者是一名45岁的白人女性，在过去10年中有哮喘和过敏性鼻炎病史。存在哮喘症状，接触灰尘和霉菌后会引发症状。五年前，她在一次常规献血筛查中偶然检测出人类嗜T淋巴细胞病毒I型（HTLV-I）血清学阳性。针对屋尘螨、粉尘螨和热带无爪螨的皮肤点刺试验呈阳性。未刺激培养物中的细胞因子水平为：干扰素γ = 1195 pg/ml，肿瘤坏死因子α = 460 pg/ml，白细胞介素5 = 41 pg/ml，白细胞介素10 = 265 pg/ml。