Brown J Martin, Attardi Laura D
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford, California 94305, USA.
Nat Rev Cancer. 2005 Mar;5(3):231-7. doi: 10.1038/nrc1560.
The inactivation of programmed cell death, or apoptosis, is central to the development of cancer. This disabling of apoptotic responses might be a major contributor both to treatment resistance and to the observation that, in many tumours, apoptosis is not the main mechanism for the death of cancer cells in response to common treatment regimens. Importantly, this suggests that other modes of cell death are involved in the response to therapy.
程序性细胞死亡（即细胞凋亡）的失活是癌症发展的核心。这种凋亡反应的失效可能是导致治疗耐药性的主要因素，同时也可以解释为何在许多肿瘤中，凋亡并非癌细胞对常用治疗方案产生死亡反应的主要机制。重要的是，这表明其他细胞死亡模式参与了对治疗的反应。
