人类逆转录病毒（人类T细胞白血病病毒）的分离与传播。

Isolation and transmission of human retrovirus (human t-cell leukemia virus).

作者信息

Popovic M, Sarin P S, Robert-Gurroff M, Kalyanaraman V S, Mann D, Minowada J, Gallo R C

出版信息

Science. 1983 Feb 18;219(4586):856-9. doi: 10.1126/science.6600519.

Abstract

Nine new isolates of human T-cell leukemia-lymphoma virus (HTLV) were obtained from cells of seven patients with malignancies of mature T cells and from two clinically normal relatives of a T-cell leukemia patient. These people were from the United States, Israel, the West Indies, and Japan. The virus was detected in the fresh T cells and was isolated from the established T-cell lines. Each isolate is closely related to the first HTLV isolate, and all the new HTLV isolates were transmitted into normal human T cells obtained from the umbilical cord blood of newborns.

摘要

从7例成熟T细胞恶性肿瘤患者的细胞以及1例T细胞白血病患者的2名临床正常亲属中获得了9株新的人类T细胞白血病-淋巴瘤病毒（HTLV）分离株。这些人来自美国、以色列、西印度群岛和日本。该病毒在新鲜T细胞中被检测到，并从已建立的T细胞系中分离出来。每株分离株都与第一株HTLV分离株密切相关，并且所有新的HTLV分离株都被传播到从新生儿脐带血中获得的正常人T细胞中。