长萼瞿麦宁A，一种从长萼瞿麦（MAXIM.）WILL.中分离得到的新型细胞毒性环肽。

Longicalycinin A, a new cytotoxic cyclic peptide from Dianthus superbus var. longicalycinus (MAXIM.) WILL.

作者信息

Hsieh Pei-Wen, Chang Fang-Rong, Wu Ching-Chung, Li Chien-Ming, Wu Kuen-Yuh, Chen Su-Li, Yen Hsin-Fu, Wu Yang-Chang

机构信息

Graduate Institute of Natural Products, Kaohsiung Medical University, Taiwan.

出版信息

Chem Pharm Bull (Tokyo). 2005 Mar;53(3):336-8. doi: 10.1248/cpb.53.336.

DOI:10.1248/cpb.53.336

PMID:15744111

Abstract

A new cyclic peptide, longicalycinin A (1), and six known compounds, vaccaroside A, dianoside A, dianoside G, 3-(4-hydroxy-3-methoxy-phenyl)propionic acid methyl ester, p-hydroxybenzoic acid, and p-hydroxybenzaldehyde were isolated from the MeOH extract of Dianthus superbus var. longicalycinus. The amino acid sequences of 1 was elucidated as cyclo(Gly(1)-Phe(2)-Tyr(3)-Pro(4)-Phe(5)-) on the basis of ESI tandem mass fragmentation analysis, chemical evidence, and extensive 2D NMR methods. Furthermore, compound 1 showed cytotoxicity to Hep G2 cancer cell line.

摘要

从长萼瞿麦的甲醇提取物中分离出一种新的环肽，长萼瞿麦素A（1），以及六种已知化合物，即 vaccaroside A、dianoside A、dianoside G、3-(4-羟基-3-甲氧基苯基)丙酸甲酯、对羟基苯甲酸和对羟基苯甲醛。基于电喷雾串联质谱碎片分析、化学证据和广泛的二维核磁共振方法，确定了1的氨基酸序列为环（甘氨酸(1)-苯丙氨酸(2)-酪氨酸(3)-脯氨酸(4)-苯丙氨酸(5)-）。此外，化合物1对Hep G2癌细胞系显示出细胞毒性。