Unsal E, Akkaya M, Walsh T F
Department of Periodontology, Ankara University, Faculty of Dentistry, Turkey.
J Clin Periodontol. 1994 May;21(5):351-5. doi: 10.1111/j.1600-051x.1994.tb00725.x.
The clinical effects of subgingivally placed 1% chlorhexidine gel (w/w) and 40% tetracycline (w/w) paste in periodontal pockets of 22 adult periodontitis patients were studied. The 2 agents were applied following scaling and root planing in pockets exceeding 4 mm. The patients were randomly divided into 3 groups: (a) scaling and root planing (SCRP) only, the control group; (b) corsodyl gel+SCRP; (c) Tetracycline paste+SCRP. Gel or paste were gently applied using a syringe with a blunt needle until the selected pocket was overfilled. Evaluations were made of clinical parameters including the plaque index (PI), gingival index (GI), bleeding index (GI-S), probing pocket depths, probing attachment levels and position of the gingival margin. The results suggested that all the treatment modalities were effective in producing statistically significant improvements in clinical parameters. It was concluded that the conventional treatment modalities were essential in the treatment of periodontal diseases, but in view of the structure of the periodontal pocket and adjacent complex root surface, subgingival drug application in certain cases, might also provide adjunctive improvement.
研究了在22例成人牙周炎患者的牙周袋内龈下放置1%洗必泰凝胶（重量/重量）和40%四环素（重量/重量）糊剂的临床效果。在深度超过4mm的牙周袋内进行龈上洁治和根面平整后应用这两种药物。患者被随机分为3组：（a）仅龈上洁治和根面平整（SCRP），为对照组；（b）洗必泰凝胶+SCRP；（c）四环素糊剂+SCRP。使用带钝头针的注射器将凝胶或糊剂轻轻注入，直至所选牙周袋充满。对包括菌斑指数（PI）、牙龈指数（GI）、出血指数（GI-S）、探诊牙周袋深度、探诊附着水平和龈缘位置等临床参数进行评估。结果表明，所有治疗方式均能在临床参数上产生具有统计学意义的显著改善。得出的结论是，传统治疗方式在牙周疾病治疗中至关重要，但鉴于牙周袋的结构和相邻复杂的根面，在某些情况下龈下用药也可能提供辅助性改善。
