Pohl Barbara S, Rössner Antje, Knöchel Walter
Abt. Biochemie, Universität Ulm, Ulm, Germany.
Int J Dev Biol. 2005;49(1):53-8. doi: 10.1387/ijdb.051977bp.
We here describe the sequences and expression patterns of three new Fox (fork head box) transcription factors in Xenopus laevis embryos. xlFoxI2, another member of subclass I, is maternally transcribed. Zygotic transcripts are first detected during neurulation and become localised to the dorsal part of epibranchial placodes. xlFoxM1 like xlFoxP1 are the first members of subclasses M and P described in Xenopus. Both genes are maternally expressed and transcripts are found during early cleavage stages in the animal blastomeres. xlFoxM1 is strongly upregulated during neurula stages and transcripts are localised in the neuroectoderm. Later, expression is found in the spinal cord, the rhombencephalon, the retina and in the branchial arches. xlFoxP1 is activated during organogenesis and is mainly expressed in the brain, head mesenchyme and in the splanchnic layer of the lateral plate mesoderm.
我们在此描述了非洲爪蟾胚胎中三种新的Fox（叉头框）转录因子的序列和表达模式。I类的另一个成员xlFoxI2是母源转录的。合子转录本在神经胚形成期间首次被检测到，并定位于鳃上神经节板的背侧部分。xlFoxM1与xlFoxP1一样，是非洲爪蟾中描述的M类和P类的首个成员。这两个基因都是母源表达的，并且在动物卵裂球的早期卵裂阶段可发现转录本。xlFoxM1在神经胚阶段强烈上调，转录本定位于神经外胚层。之后，在脊髓、后脑、视网膜和鳃弓中发现表达。xlFoxP1在器官发生期间被激活，主要在脑、头部间充质和侧板中胚层的脏层中表达。
