Kendler K S, Silberg J L, Neale M C, Kessler R C, Heath A C, Eaves L J
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.
Psychol Med. 1992 Feb;22(1):85-100. doi: 10.1017/s0033291700032761.
Symptoms during the premenstrual and menstrual phases of the female reproductive cycle were assessed in 827 pairs of female same-sex twins from a population-based registry. By conventional factor analysis, premenstrual and menstrual symptoms were relatively independent of one another and of baseline 'neurotic' symptoms (i.e. anxiety, depression and somatization). Familial resemblance for menstrual and premenstrual symptoms was due solely to genetic factors with heritability estimates of 39.2% and 35.1%, respectively. Multivariate genetic analysis revealed distinct genetic and environmental factors for menstrual, premenstrual and neurotic symptoms. The genes and individual-specific experiences that predispose to premenstrual symptoms appear to be largely distinct from those which predispose either to menstrual or to neurotic symptoms. The generalizability of these results may be limited because only a modest number of premenstrual and menstrual symptoms were assessed, all by retrospective self-report.
在一项基于人群登记的研究中，对827对女性同卵双胞胎的女性生殖周期中的经前和经期症状进行了评估。通过传统因素分析，经前症状和经期症状相对彼此独立，且与基线“神经症性”症状（即焦虑、抑郁和躯体化症状）无关。经期症状和经前症状的家族相似性完全归因于遗传因素，遗传率估计分别为39.2%和35.1%。多变量遗传分析揭示了经期、经前和神经症性症状的不同遗传和环境因素。导致经前症状的基因和个体特定经历似乎与导致经期症状或神经症性症状的基因和经历在很大程度上不同。这些结果的普遍性可能有限，因为仅通过回顾性自我报告评估了数量有限的经前和经期症状。
