Kim Young-Ju, Hong Yun-Chul, Lee Kwan-Hee, Park Heon Joo, Park Eun Ae, Moon Hye-Sung, Ha Eun-Hee
Department of Obstetrics and Gynecology, Ewha Womans University College of Medicine, Seoul, South Korea.
Reprod Toxicol. 2005 Mar-Apr;19(4):487-92. doi: 10.1016/j.reprotox.2004.10.007.
The purpose of this study is to evaluate the role of maternal oxidative stress in lowering neonatal birth weight. Women (N=261) with singleton pregnancy were analyzed for biomarker levels of oxidative stress after recruitment at the time of hospitalization for delivery in Korea between 2000 and 2001. Among the neonates, 247 births were full-term infants and 14 births were pre-term infants. Biomarkers measured for oxidative stress were maternal urinary 8-hydroxydeoxyguanosine (8-OH-dG) and malondialdehyde (MDA). The women with pre-term infants had higher concentrations of urinary 8-OH-dG and MDA than those with full-term babies. The concentrations of maternal urinary 8-OH-dG and MDA were inversely associated with birth weight of full-term deliveries after adjusting for potential confounders including maternal age, body mass index, dietary intake, alcohol consumption, smoking exposure, occupational status, and neonatal sex (P<0.05). This study demonstrates that increase of 8-OH-dG and MDA concentrations in urine of pregnant women were associated with reduced birth weight in full-term deliveries.
本研究的目的是评估母体氧化应激在降低新生儿出生体重方面的作用。2000年至2001年在韩国分娩住院时招募了261名单胎妊娠女性，分析她们氧化应激的生物标志物水平。在这些新生儿中，247例为足月儿，14例为早产儿。用于测量氧化应激的生物标志物是母体尿8-羟基脱氧鸟苷（8-OH-dG）和丙二醛（MDA）。早产婴儿的母亲尿8-OH-dG和MDA浓度高于足月婴儿的母亲。在调整了包括母亲年龄、体重指数、饮食摄入、饮酒、吸烟暴露、职业状况和新生儿性别等潜在混杂因素后，母体尿8-OH-dG和MDA浓度与足月分娩的出生体重呈负相关（P<0.05）。本研究表明，孕妇尿液中8-OH-dG和MDA浓度的增加与足月分娩时出生体重降低有关。
