Portney Nathaniel G, Singh Krishna, Chaudhary Sumit, Destito Giuseppe, Schneemann Anette, Manchester Marianne, Ozkan Mihrimah
Department of Chemical and Environmental Engineering, University of California, Riverside, CA 92521, USA.
Langmuir. 2005 Mar 15;21(6):2098-103. doi: 10.1021/la047525f.
Viruses are exemplary models in nanoassembly for their regular geometries, well characterized surface properties, and nanoscale dimensions. Armed with versatile tools aimed at site-directed mutagenesis to modify the virion's surface, conjugation chemistry for capsid coupling, and manipulation of nanoparticles, we have demonstrated nanoscale assembly of inorganic carbon nanotubes and quantum dots with engineered viruses to produce an intimate array of hybrid structures.
病毒因其规则的几何形状、特征明确的表面性质和纳米级尺寸,成为纳米组装领域的典范模型。借助旨在进行定点诱变以修饰病毒粒子表面的多种工具、用于衣壳偶联的共轭化学方法以及对纳米颗粒的操控手段,我们已证明无机碳纳米管和量子点与经过工程改造的病毒能够进行纳米级组装,从而产生紧密排列的混合结构阵列。