纳米粒子在基因治疗和磁共振成像中的应用。
The application of nanoparticles in gene therapy and magnetic resonance imaging.
机构信息
Facultad de Farmacia, Departamento de Química Física II, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Universidad Complutense de Madrid, Madrid, Spain.
出版信息
Microsc Res Tech. 2011 Jul;74(7):577-91. doi: 10.1002/jemt.20992. Epub 2011 Apr 11.
Abstract
The combination of nanoparticles, gene therapy, and medical imaging has given rise to a new field known as gene theranostics, in which a nanobioconjugate is used to diagnose and treat the disease. The process generally involves binding between a vector carrying the genetic information and a nanoparticle, which provides the signal for imaging. The synthesis of this probe generates a synergic effect, enhancing the efficiency of gene transduction and imaging contrast. We discuss the latest approaches in the synthesis of nanoparticles for magnetic resonance imaging, gene therapy strategies, and their conjugation and in vivo application.
摘要
纳米粒子、基因治疗和医学成像的结合产生了一个新的领域，称为基因治疗诊断学，其中一种纳米生物缀合物被用于诊断和治疗疾病。该过程通常涉及携带遗传信息的载体与纳米粒子之间的结合，纳米粒子提供成像信号。该探针的合成产生协同效应，提高基因转导和成像对比的效率。我们讨论了用于磁共振成像、基因治疗策略及其缀合和体内应用的纳米粒子合成的最新方法。
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