Department of Molecular Biology and Center of Integrative Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA.
Nanomedicine. 2010 Oct;6(5):634-41. doi: 10.1016/j.nano.2010.04.005. Epub 2010 Apr 28.
Nanomaterials have been developed for potential applications in biomedicine, such as tissue-specific imaging and drug delivery. There are many different platforms under development, each with advantages and disadvantages, but viral nanoparticles (VNPs) are particularly attractive because they are naturally occurring nanomaterials, and as such they are both biocompatible and biodegradable. VNPs can be designed and engineered using both genetic and chemical protocols. The use of VNPs has evolved rapidly since their introduction 20 years ago, encompassing numerous chemistries and modification strategies that allow the functionalization of VNPs with imaging reagents, targeting ligands, and therapeutic molecules. This review discusses recent advances in the design of "smart" targeted VNPs for therapeutic and imaging applications.
This review focuses on viral nanoparticles, which are considered attractive naturally occurring nanomaterials due to their inherent biocompatibility and biodegradability. These can be used as imaging reagents, targeting ligands and therapeutic molecules.
纳米材料已经被开发出来，用于生物医药的潜在应用，例如组织特异性成像和药物输送。有许多不同的平台正在开发中，每个平台都有其优缺点，但病毒纳米颗粒（VNPs）特别有吸引力，因为它们是天然存在的纳米材料，因此既具有生物相容性又具有生物降解性。VNPs 可以使用遗传和化学方案进行设计和工程化。自 20 年前引入以来，VNPs 的使用迅速发展，涵盖了许多化学和修饰策略，允许将成像试剂、靶向配体和治疗分子功能化到 VNPs 上。这篇综述讨论了用于治疗和成像应用的“智能”靶向 VNPs 的设计的最新进展。
这篇综述侧重于病毒纳米颗粒，它们被认为是有吸引力的天然存在的纳米材料，因为它们具有固有的生物相容性和生物降解性。这些可以用作成像试剂、靶向配体和治疗分子。
