Katti Kavita K, Kattumuri Vijaya, Bhaskaran Sharanya, Katti Kattesh V, Kannan Raghuraman
Department of Radiology, Rm #106 Alton Bldg Laboratories, 301 Business loop 70W, University of Missouri-Columbia, Columbia, MO-65211.
Int J Green Nanotechnol Biomed. 2009 Jan 1;1(1):B53-B59. doi: 10.1080/19430850902983848.
This letter describes a general method for the preparation of carbohydrate coated gold nanoparticles. The generality of this method has been demonstrated by surface coating AuNPs with the following sugars: glucose (monosaccharide); sucrose, maltose, or lactose (disaccharides); raffinose (trisaccharide); and starch (polysaccharide). The non-toxic, water-soluble phosphino aminoacid P(CH(2)NHCH(CH(3)-)COOH)(3), THPAL, has been used as a reducing agent in this process. The sizes of sugar coated AuNPs that have been generated in this study are: 30 ± 8 nm (Glucose), 10 ± 6 nm (sucrose), 8 ± 2 nm (maltose), 3 ± 1 nm (lactose), 6 ± 2 nm (raffinose), and 39 ± 9 nm (starch).
这封信描述了一种制备碳水化合物包覆金纳米颗粒的通用方法。通过用以下糖类包覆金纳米颗粒(AuNPs)证明了该方法的通用性:葡萄糖(单糖);蔗糖、麦芽糖或乳糖(二糖);棉子糖(三糖);以及淀粉(多糖)。无毒的水溶性膦基氨基酸P(CH(2)NHCH(CH(3)-)COOH)(3),即THPAL,在此过程中用作还原剂。本研究中生成的糖包覆金纳米颗粒的尺寸为:30±8纳米(葡萄糖)、10±6纳米(蔗糖)、8±2纳米(麦芽糖)、3±1纳米(乳糖)、6±2纳米(棉子糖)和39±9纳米(淀粉)。