Lee T H, Chen S S, Su S L, Yang S S
Department of Neurology, Chang Gung Memorial Hospital, Taipei, Taiwan, Republic of China.
Clin Neuropharmacol. 1992 Feb;15(1):56-62.
Four cases of baclofen intoxication are reported, with a review of 33 cases from the literature. Analysis of these 37 cases suggests that there are two types of baclofen intoxication syndrome. Patients with acute intoxication present with four major clinical manifestations: encephalopathy (disturbance of consciousness and/or seizure), respiratory depression, muscular hypotonia, and generalized hyporeflexia. Patients with chronic intoxication present with hallucinosis, impaired memory, catatonia, or acute mania. The acute intoxication syndrome has a faster onset, shorter duration, more severe clinical manifestations, and higher incidence of seizures than the chronic intoxication syndrome. Baclofen intoxication, although it may cause grave encephalopathic manifestations and electroencephalographic findings, has a benign outcome if actively managed.
本文报告了4例巴氯芬中毒病例，并对文献中的33例病例进行了回顾。对这37例病例的分析表明，巴氯芬中毒综合征有两种类型。急性中毒患者有四种主要临床表现：脑病（意识障碍和/或癫痫发作）、呼吸抑制、肌张力减退和全身反射减弱。慢性中毒患者有幻觉、记忆障碍、紧张症或急性躁狂。与慢性中毒综合征相比，急性中毒综合征起病更快、病程更短、临床表现更严重、癫痫发作发生率更高。巴氯芬中毒虽然可能导致严重的脑病表现和脑电图结果，但如果积极治疗，预后良好。
