Macocinschi Doina, Filip Daniela, Vlad Stelian, Cristea Mariana, Butnaru Maria
Petru Poni Institute of Macromolecular Chemistry, Iasi, Romania.
J Mater Sci Mater Med. 2009 Aug;20(8):1659-68. doi: 10.1007/s10856-009-3731-3. Epub 2009 Mar 19.
Polyurethanes are one of the most popular groups of biomaterials applied for medical devices. Their segmented block copolymeric character endows them a wide range of versatility in terms of tailoring their physical properties, blood and tissue compatibility. Polyester- and polyether-urethanes have been modified with hydroxypropyl cellulose aiming the change of their surface and bulk characteristics to confer them biomaterial qualities. In this respect, dynamic contact angle measurements, dynamic mechanical analyses accompanied by mechanical testing have been done. Platelet adhesion test has been carried out in vitro and the use of hydroxypropyl cellulose in the polyurethane matrix reduces the platelet adhesion and therefore recommends them as candidates for biocompatible materials.
聚氨酯是应用于医疗设备的最受欢迎的生物材料类别之一。它们的嵌段共聚物特性使其在调整物理性能、血液和组织相容性方面具有广泛的通用性。聚酯型和聚醚型聚氨酯已用羟丙基纤维素进行了改性，目的是改变其表面和整体特性，赋予它们生物材料的品质。在这方面，已经进行了动态接触角测量、伴随力学测试的动态力学分析。体外进行了血小板黏附试验，羟丙基纤维素在聚氨酯基体中的使用减少了血小板黏附，因此推荐它们作为生物相容性材料的候选者。
