Xu Li-Chong, Bauer James W, Siedlecki Christopher A
Department of Surgery, Biomedical Engineering Institute, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Department of Bioengineering, Biomedical Engineering Institute, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, United States.
Colloids Surf B Biointerfaces. 2014 Dec 1;124:49-68. doi: 10.1016/j.colsurfb.2014.09.040. Epub 2014 Sep 28.
Blood coagulation and platelet adhesion remain major impediments to the use of biomaterials in implantable medical devices. There is still significant controversy and question in the field regarding the role that surfaces play in this process. This manuscript addresses this topic area and reports on state of the art in the field. Particular emphasis is placed on the subject of surface engineering and surface measurements that allow for control and observation of surface-mediated biological responses in blood and test solutions. Appropriate use of surface texturing and chemical patterning methodologies allow for reduction of both blood coagulation and platelet adhesion, and new methods of surface interrogation at high resolution allow for measurement of the relevant biological factors.
血液凝固和血小板黏附仍然是生物材料在植入式医疗设备中应用的主要障碍。关于表面在这一过程中所起的作用，该领域仍存在重大争议和问题。本手稿论述了这一主题领域，并报告了该领域的最新进展。特别强调了表面工程和表面测量主题，这些主题能够控制和观察血液及测试溶液中表面介导的生物反应。合理使用表面纹理化和化学图案化方法可以减少血液凝固和血小板黏附，而高分辨率表面探测新方法能够测量相关生物因子。
