Sette Alessandro, Fleri Ward, Peters Bjoern, Sathiamurthy Muthuraman, Bui Huynh-Hoa, Wilson Stephen
La Jolla Institute for Allegy and Immunology, San Diego, CA 92121, USA.
Immunity. 2005 Feb;22(2):155-61. doi: 10.1016/j.immuni.2005.01.009.
The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), recently awarded 14 contracts to fund the Large-Scale Antibody and T Cell Epitope Discovery Program. This initiative is designed to identify immune epitopes from selected infectious agents utilizing complementary methods for epitope discovery. NIAID will make information on each newly identified epitope freely available to scientists worldwide through the Immune Epitope Database and Analysis Resource (IEDB), currently under development. On October 12-14, 2004, representatives of NIAID met in San Diego, California, with a group of investigators from various research institutions to discuss progress and plans for the large-scale epitope discovery projects and for the establishment of the IEDB. It is anticipated that these initiatives will establish detailed maps of immune reactions toward several important complex pathogens, which in turn will foster development of new diagnostic, immune-based therapeutic, and vaccine programs. Herein is an account of the meeting and its results.
美国国立卫生研究院（NIH）下属的国立过敏与传染病研究所（NIAID）最近授予了14项合同，为大规模抗体和T细胞表位发现计划提供资金。该计划旨在利用互补的表位发现方法，从选定的传染病原体中识别免疫表位。NIAID将通过目前正在开发的免疫表位数据库和分析资源（IEDB），向全球科学家免费提供每个新识别表位的信息。2004年10月12日至14日，NIAID的代表在加利福尼亚州圣地亚哥与来自各研究机构的一组研究人员会面，讨论大规模表位发现项目以及建立IEDB的进展和计划。预计这些计划将绘制出针对几种重要复杂病原体的免疫反应详细图谱，进而推动新的诊断、基于免疫的治疗和疫苗计划的发展。本文介绍了此次会议及其成果。
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