来自新几内亚 Culcita 海星的生物活性海星皂苷。

Bioactive asterosaponins from the starfish Culcita novaeguineae.

作者信息

Tang Hai-Feng, Yi Yang-Hua, Li Ling, Sun Peng, Zhang San-Qi, Zhao Yue-Ping

机构信息

Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, People's Republic of China.

出版信息

J Nat Prod. 2005 Mar;68(3):337-41. doi: 10.1021/np0401617.

DOI:10.1021/np0401617

PMID:15787432

Abstract

Two new sulfated steroidal pentaglycosides (asterosaponins), novaeguinosides I (2) and II (3), along with the known regularoside B (1) were isolated from the starfish Culcita novaeguineae. Their structures were elucidated by extensive NMR techniques as well as chemical evidence. The new asterosaponins showed marginal in vitro cytotoxicity against two human tumor cell lines.

摘要

从新几内亚 Culcita 海星中分离出两种新的硫酸化甾体五糖苷（海星皂苷），新几内亚海星皂苷 I（2）和 II（3），以及已知的规则皂苷 B（1）。通过广泛的核磁共振技术以及化学证据阐明了它们的结构。新的海星皂苷对两种人类肿瘤细胞系显示出微弱的体外细胞毒性。