两种新的 asterosaponins，即 archasterosides A 和 B，来自越南海星 Archaster typicus，具有抗癌特性。

Two new asterosaponins, archasterosides A and B, from the Vietnamese starfish Archaster typicus and their anticancer properties.

机构信息

Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, Vladivostok, Russia.

出版信息

Bioorg Med Chem Lett. 2010 Jun 15;20(12):3826-30. doi: 10.1016/j.bmcl.2010.04.005. Epub 2010 Apr 9.

DOI:10.1016/j.bmcl.2010.04.005

PMID:20493687

Abstract

New asterosaponins archasterosides A (1), B (2), and the known regularoside A (3) were isolated from the Vietnamese starfish Archaster typicus and structurally elucidated by extensive NMR techniques and chemical transformations. Compounds 1-3 showed moderate cytotoxic activities against HeLa and mouse JB6 P(+) Cl41 cell lines. The most active, 2, induced basal AP-1- and p53-, but not NF-kappaB-transcriptional activations in JB6 Cl41 cells.

摘要

从越南星盘 Asterias typicus 中分离得到三种新的甾醇皂苷类化合物 asterosaponins archasterosides A (1)、B (2) 和已知的 regularoside A (3)，并通过广泛的 NMR 技术和化学转化进行了结构解析。化合物 1-3 对 HeLa 和小鼠 JB6 P(+) Cl41 细胞系表现出中等的细胞毒性活性。其中最具活性的 2 可诱导 JB6 Cl41 细胞中基础 AP-1 和 p53 的转录激活，但不诱导 NF-κB 的转录激活。