来自有柄瓶尔小草的高异黄酮类化合物。

Homoflavonoids from Ophioglossum petiolatum.

作者信息

Lin Yun-Lian, Shen Chien-Chang, Huang Yeh-Jeng, Chang Ying-Ying

机构信息

National Research Institute of Chinese Medicine, Taipei 112, Taiwan.

出版信息

J Nat Prod. 2005 Mar;68(3):381-4. doi: 10.1021/np0401819.

DOI:10.1021/np0401819

PMID:15787440

Abstract

Six homoflavonoids, ophioglonin (1), ophioglonin 7-O-beta-D-glucopyranoside (2), ophioglonol (3), ophioglonol prenyl ether (4), ophioglonol 4'-O-beta-D-glucopyranoside (5), and isoophioglonin 7-O-beta-D-glucopyranoside (6), together with five known compounds, quercetin, luteolin, kaempferol, 3,5,7,3',4'-pentahydroxy-8-prenylflavone, and quercetin 3-O-methyl ether, were isolated from Ophioglossum petiolatum. Their structures were elucidated by analysis of spectroscopic data and chemical evidence. Compounds 1 and quercetin 3-O-methyl ether showed slight anti-HBV surface antigen activity at 25 microM.

摘要

从有柄瓶尔小草中分离出6种高异黄酮，蛇苔黄素（1）、蛇苔黄素7-O-β-D-吡喃葡萄糖苷（2）、蛇苔醇（3）、蛇苔醇异戊烯基醚（4）、蛇苔醇4'-O-β-D-吡喃葡萄糖苷（5）和异蛇苔黄素7-O-β-D-吡喃葡萄糖苷（6），以及5种已知化合物，槲皮素、木犀草素、山柰酚、3,5,7,3',4'-五羟基-8-异戊烯基黄酮和槲皮素3-O-甲基醚。通过光谱数据分析和化学证据阐明了它们的结构。化合物1和槲皮素3-O-甲基醚在25微摩尔浓度时表现出轻微的抗乙肝表面抗原活性。