一种用于体内癌症成像的生物磁系统。
A biomagnetic system for in vivo cancer imaging.
作者信息
Flynn E R, Bryant H C
机构信息
Senior Scientific, Albuquerque, NM 87111, USA.
出版信息
Phys Med Biol. 2005 Mar 21;50(6):1273-93. doi: 10.1088/0031-9155/50/6/016. Epub 2005 Mar 2.
Abstract
An array of highly sensitive biomagnetic sensors of the superconducting quantum interference detector (SQUID) type can identify disease in vivo by detecting and imaging microscopic amounts of nanoparticles. We describe in detail procedures and parameters necessary for implementation of in vivo detection through the use of antibody-labelled magnetic nanoparticles as well as methods of determining magnetic nanoparticle properties. We discuss the weak field magnetic sensor SQUID system, the method of generating the magnetic polarization pulse to align the magnetic moments of the nanoparticles, and the measurement techniques to measure their magnetic remanence fields following this pulsed field. We compare these results to theoretical calculations and predict optimal properties of nanoparticles for in vivo detection.
摘要
一系列超导量子干涉探测器（SQUID）类型的高灵敏度生物磁传感器能够通过检测和成像微量纳米颗粒来在体内识别疾病。我们详细描述了通过使用抗体标记的磁性纳米颗粒进行体内检测所需的程序和参数，以及确定磁性纳米颗粒特性的方法。我们讨论了弱场磁传感器SQUID系统、产生磁极化脉冲以使纳米颗粒磁矩对齐的方法，以及在该脉冲场之后测量其剩余磁场的测量技术。我们将这些结果与理论计算进行比较，并预测用于体内检测的纳米颗粒的最佳特性。
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