了解HLA和KIR基因组合如何影响疾病。
Understanding how combinations of HLA and KIR genes influence disease.
作者信息
Rajagopalan Sumati, Long Eric O
机构信息
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD 20852, USA.
出版信息
J Exp Med. 2005 Apr 4;201(7):1025-9. doi: 10.1084/jem.20050499.
Abstract
Combinations of HLA and killer cell immunoglobulin-like receptor (KIR) genes have been associated with diseases as diverse as autoimmunity, viral infections, reproductive failure, and now cancer. Much as early observations of disease associations with HLA polymorphism preceded a detailed knowledge of HLA recognition by T cell receptors, the recently reported disease associations with HLA-KIR gene combinations beg for a better understanding of the underlying mechanisms.
摘要
人类白细胞抗原（HLA）基因与杀伤细胞免疫球蛋白样受体（KIR）基因的组合已被证实与多种疾病相关，如自身免疫性疾病、病毒感染、生殖功能衰竭，现在还包括癌症。就像早期观察到疾病与HLA多态性的关联早于对T细胞受体识别HLA的详细了解一样，最近报道的疾病与HLA-KIR基因组合的关联迫切需要我们更好地理解其潜在机制。
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