主动脉瓣狭窄：它仅仅是一个退行性过程还是一个活跃的动脉粥样硬化过程？
Aortic stenosis: is it simply a degenerative process or an active atherosclerotic process?
作者信息
Hughes Bradley R, Chahoud Georges, Mehta J L
出版信息
Clin Cardiol. 2005 Mar;28(3):111-4. doi: 10.1002/clc.4960280303.
Abstract
Aortic stenosis remains the most common cause of cardiac valve replacement in developed countries. The prevalence of this condition increases with age, and many of the risk factors for coronary artery disease also appear related to the development and progression of aortic stenosis. Recent studies also suggest a relationship between calcium and lipid accumulation in both coronary artery disease and aortic stenosis. Most important, there is growing evidence that aggressive treatment of coronary artery disease risk factors, particularly hyperlipidemia, may influence the progression of aortic stenosis. In this article the current literature is reviewed as it relates to vascular biology, pathogenesis of aortic valve disease, and current and newly emerging management approaches in the care of the patient with aortic stenosis.
摘要
在发达国家，主动脉瓣狭窄仍然是心脏瓣膜置换最常见的原因。这种疾病的患病率随年龄增长而增加，而且许多冠状动脉疾病的危险因素似乎也与主动脉瓣狭窄的发生和发展有关。最近的研究还表明，在冠状动脉疾病和主动脉瓣狭窄中，钙和脂质积累之间存在关联。最重要的是，越来越多的证据表明，积极治疗冠状动脉疾病的危险因素，尤其是高脂血症，可能会影响主动脉瓣狭窄的进展。本文将对当前与血管生物学、主动脉瓣疾病发病机制以及主动脉瓣狭窄患者当前和新出现的管理方法相关的文献进行综述。
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