Ströch Karsten, Zeeck Axel, Antal Noémi, Fiedler Hans-Peter
Institut für Organische und Biomolekulare Chemie, Universität Gottingen, Tammannstr. 2, D-37077 Göttingen, Germany.
J Antibiot (Tokyo). 2005 Feb;58(2):103-10. doi: 10.1038/ja.2005.13.
A detailed screening of the secondary metabolite pattern from Micromonospora sp. strain Tü 6368 resulted in the isolation of ten compounds belonging to five different structural families. The structures of the novel compounds 1-(alpha-ribofuranosyl)-lumichrome (3), retymicin (7), galtamycin B (11) and saquayamycin Z (14) were assigned by spectroscopic methods and chemical transformations. This strain fits our hypothesis that the metabolite analysis of biosynthetically talented strains leads readily to novel compounds.
对小单孢菌属菌株Tü 6368的次生代谢产物模式进行详细筛选，结果分离出了属于五个不同结构家族的十种化合物。通过光谱方法和化学转化确定了新型化合物1-(α-呋喃核糖基)-光色素（3）、瑞替米星（7）、加塔霉素B（11）和沙奎霉素Z（14）的结构。该菌株符合我们的假设，即对具有生物合成天赋的菌株进行代谢产物分析很容易得到新型化合物。
