Mountessou Bel Youssouf G, Mouafon Iliassou L, Maharjan Rukesh, Tchamgoue Joseph, Tiani Gesquiere Laure M, Dibouloul Patrick, Choudhary Muhammad I, Kouam Simeon F
Department of Chemistry, Higher Teacher Training College, University of Yaoundé I P. O. Box 47 Yaoundé Cameroon
Department of Pharmaceutical Sciences, Tshwane University of Technology P. O. Box 0083 Pretoria South Africa.
RSC Adv. 2025 Jul 17;15(31):25441-25449. doi: 10.1039/d5ra04180e. eCollection 2025 Jul 15.
Four previously undescribed phenazine-derived pigments (1-4), along with seventeen known compounds, were isolated from a strain cultured on solid rice medium. Structural elucidation of the new compounds was achieved through extensive spectroscopic analysis, while known compounds were identified by comparison with literature data. The antimicrobial and cytotoxic activities of the isolated compounds were assessed. Compounds 2, 5, and 11 exhibited weak antifungal activity against at 200 μM, while compounds 5, 6, 11, 12, 15, and 20 demonstrated moderate antibacterial effects against at the same concentration. Notably, compound 4 showed significant cytotoxicity against breast cancer cells (MCF-7, IC = 6.8 μM), and moderate cytotoxicity against cervical cancer cells (HeLa, IC = 25.0 μM). Moreover, the known quinone-derived pigments 10, 12, and 13 displayed potent cytotoxic activities against the three tested cancer cell lines (MCF-7, PC3, and HeLa). These results highlight the potential of these compounds as promising bioactive agents for cancer treatment.
从在固体大米培养基上培养的一株菌株中分离出四种先前未描述的吩嗪衍生色素（1-4）以及十七种已知化合物。通过广泛的光谱分析对新化合物进行了结构解析，而已知化合物则通过与文献数据比较进行鉴定。对分离出的化合物的抗菌和细胞毒性活性进行了评估。化合物2、5和11在200μM时对[具体真菌名称未给出]表现出弱抗真菌活性，而化合物5、6、11、12、15和20在相同浓度下对[具体细菌名称未给出]表现出中等抗菌效果。值得注意的是，化合物4对乳腺癌细胞（MCF-7，IC = 6.8μM）显示出显著的细胞毒性，对宫颈癌细胞（HeLa，IC = 25.0μM）显示出中等细胞毒性。此外，已知的醌衍生色素10、12和13对三种测试癌细胞系（MCF-7、PC3和HeLa）表现出强大的细胞毒性活性。这些结果突出了这些化合物作为有前景的癌症治疗生物活性剂的潜力。
