吡咯孢菌素A，一种来自小单孢菌属C39217-R109-7的新型抗肿瘤抗生素。II. 分离、物理化学性质、光谱研究及X射线分析。
Pyrrolosporin A, a new antitumor antibiotic from Micromonospora sp. C39217-R109-7. II. Isolation, physico-chemical properties, spectroscopic study and X-ray analysis.
作者信息
Schroeder D R, Colson K L, Klohr S E, Lee M S, Matson J A, Brinen L S, Clardy J
机构信息
Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.
出版信息
J Antibiot (Tokyo). 1996 Sep;49(9):865-72. doi: 10.7164/antibiotics.49.865.
Pyrrolosporin A (1) is a new macrolide antitumor antibiotic possessing an unusual spiro-alpha-acyltetronic acid moiety. The antibiotic was isolated from the fermentation broth of Micromonospora sp. by vacuum liquid chromatography, crystallization and reversed phase HPLC (C18). The structure was determined by a combination of NMR, MS, IR, UV, X-ray analysis and degradation studies.
吡咯孢菌素A（1）是一种新型大环内酯类抗肿瘤抗生素，具有不寻常的螺环-α-酰基四氢吡喃酸部分。该抗生素通过真空液相色谱、结晶和反相高效液相色谱（C18）从微小单孢菌属的发酵液中分离得到。其结构通过核磁共振（NMR）、质谱（MS）、红外光谱（IR）、紫外光谱（UV）、X射线分析和降解研究相结合的方法确定。
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