Park Seung Ha, Park Dong Il, Kim Sang Hoon, Kim Hong Joo, Cho Yong Kyun, Sung In Kyung, Sohn Chong Il, Jeon Woo Kyu, Kim Byung Ik, Keum Dong Keuk
Department of Internal Medicine, Kangbuk Samsung Hospital, Seoul, Korea.
Dig Dis Sci. 2005 Apr;50(4):626-9. doi: 10.1007/s10620-005-2547-3.
We conducted a pilot study aimed at comparing the efficacy of the standard OAC (omeprazole-amoxicillin-clarithromycin) regimen with a combination of the OAC regimen and aspirin (OACA). Follow-up endoscopic findings showed that the previous ulcers were completely healed in all subjects. The eradication rates (per protocol) were 80.3% (49/61) in the OAC group and 86.7% (52/60) in the OACA group. The eradication rate was not significantly different between the two groups. The most common adverse event was a bad taste, and the overall adverse events were similar in the two groups. The combination of the OAC regimen and aspirin was not significantly superior to the standard OAC regimen, but it was well tolerated in a group of patients with peptic ulcer disease. Its potential for clinical use to augment the efficacy of H. pylori eradication may warrant further investigation.
我们开展了一项初步研究，旨在比较标准OAC（奥美拉唑-阿莫西林-克拉霉素）方案与OAC方案联合阿司匹林（OACA）的疗效。随访内镜检查结果显示，所有受试者先前的溃疡均完全愈合。OAC组的根除率（符合方案分析）为80.3%（49/61），OACA组为86.7%（52/60）。两组的根除率无显著差异。最常见的不良事件是味觉不佳，两组的总体不良事件相似。OAC方案与阿司匹林联合使用并不显著优于标准OAC方案，但在一组消化性溃疡疾病患者中耐受性良好。其在临床上增强幽门螺杆菌根除疗效的潜力可能值得进一步研究。
