Salas-Salvadó Jordi, Casas-Agustench Patricia, Murphy Michelle M, López-Uriarte Patricia, Bulló Monica
Human Nutrition Unit, Department of Biochemistry and Biotech-nology, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili, C/Sant Llorenc, 21, 43201 Reus, Spain.
Asia Pac J Clin Nutr. 2008;17 Suppl 1:333-6.
Inflammation is one of the recognised mechanisms involved in the development of atherosclerotic plaque and insulin resistance. Inflammatory or endothelial markers such as C-Reactive Protein (CRP), Interleukin-6 (IL-6), fibrinogen, Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intracellular Adhesion Molecule-1 (ICAM-1) have been identified as independent predictors of cardiovascular disease (CVD) or diabetes in human prospective studies. Epidemiological and clinical studies suggest that some dietary factors, such as n-3 polyunsaturated fatty acids, antioxidant vitamins, dietary fiber, L-arginine and magnesium may play an important role in modulating inflammation. The relationship observed between frequent nut consumption and the reduced risk of cardiovascular mortality and type 2 diabetes in some prospective studies could be explained by the fact that nuts are rich in all of these modulator nutrients. In fact, frequent nut consumption has been associated with lower concentrations of some peripheral inflammation markers in cross-sectional studies. Nut consumption has also been shown to decrease the plasma concentration of CRP, IL-6 and some endothelial markers in recent clinical trials.
炎症是动脉粥样硬化斑块形成和胰岛素抵抗发展过程中公认的机制之一。在人类前瞻性研究中，炎症或内皮标志物，如C反应蛋白（CRP）、白细胞介素-6（IL-6）、纤维蛋白原、血管细胞黏附分子-1（VCAM-1）和细胞间黏附分子-1（ICAM-1）已被确定为心血管疾病（CVD）或糖尿病的独立预测指标。流行病学和临床研究表明，一些饮食因素，如n-3多不饱和脂肪酸、抗氧化维生素、膳食纤维、L-精氨酸和镁，可能在调节炎症方面发挥重要作用。在一些前瞻性研究中观察到的经常食用坚果与心血管疾病死亡率降低和2型糖尿病风险降低之间的关系，可以用坚果富含所有这些调节性营养素这一事实来解释。事实上，在横断面研究中，经常食用坚果与某些外周炎症标志物浓度较低有关。在最近的临床试验中，食用坚果也已被证明可降低血浆中CRP、IL-6和一些内皮标志物的浓度。
